Centre research on innovative drug delivery using functionalised nanoparticles has recently been published in the prestigious journal Adgewandte Chemie (IF 13.45) and has been recommended as a HOT article by the journal editor.


pH-Responsive Nutraceutical–Mesoporous Silica Nanoconjugates with Enhanced Colloidal Stability
Remy Guillet-Nicolas, Amirali Popat, Jean-Luc Bridot, Gregory Monteith, Shi Zhang Qiao, and Freddy Kleitz  
Volume 125, Issue 8, pages 2374–2378, February 18, 2013


An innovative platform for targeted oral drug delivery is proposed based on the functionalization of drug/dye-loaded mesoporous silica nanoparticles (MSNs) with a biodegradable nutraceutical (β-lactoglobulin). The attachment of the nutraceutical not only protects the drug/dye from leaching in acidic environment, but also effectively allows their release in desired basic sites (pH 7.4).

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